Suchergebnisse

During the politico-military events of January 1866 in Spain, hundreds of Spanish soldiers, under the command of General Prim, crossed the border to exile in Portugal. A few months later, the Portuguese government sent over two hundred and fifty of these exiles to the Azores, some of whom spent more than two years there. The main purpose of this paper is to ascertain, through a study of the Azorean press, how they were received and treated by the island authorities and citizens, and how they adapted to life on the islands. ; En los sucesos político-militares de enero de 1866 en España, centenares de militares españoles, bajo el mando del general Prim, pasaron la frontera, exiliándose en Portugal. Meses después, el gobierno portugués envió a las Azores más de 250 de esos exiliados, parte de los cuales permanecieron más de dos años allí. El objetivo principal de este trabajo es el comprender, a la luz de la prensa periódica, cómo fueron recibidos y tratados por las autoridades y los ciudadanos insulares, cómo se adaptaron a la vida de las islas y se enfrentaron a aquella situación.

O consumo da carne de pescado no Brasil é muito baixo em relação ao consumo de outras carnes, devido a problemas na distribuição e comercialização destes, com isso é imprescindível que se busque novas alternativas para a utilização desta matéria-prima, com o fim de transformá-la em mercadorias aceitáveis pela população como produtos prontos ou semi-prontos. O experimento teve como objetivo avaliar a aceitabilidade de almôndegas de peixe desenvolvidas com diferentes ligantes sendo, F1 (farinha de pão), F2 (batata e trigo) e F3 (farinha de rosca e trigo). O pescado usado como matéria-prima foi o tucunaré (Cichla monoculus) onde foi feito a filetagem depois moído e separado em bandejas plásticas e acondicionado no freezer para a preparação das almôndegas. Realizou-se uma análise sensorial utilizando-se 60 provadores, onde constatou que não houve diferença significativa entre as três formulações. A partir dos resultados analisados, a almôndega feita com a 1formulação dois foi à mais preferida entre os provadores, com um índice de aceitação de 82,96% e média global de 7,47.

Chronic respiratory diseases (CRDs) are major non-communicable diseases (NCDs) that induce a significant burden. Asthma often occurs along the life cycle from early childhood, affecting 30 million children and adults under 45 years of age in Europe. Chronic obstructive pulmonary disease (COPD) has an estimated annual death rate of over 3 million people globally. The annual direct and indirect costs in the 28 European Union (EU) countries due to COPD or asthma are estimated at 48 billion euros and 34 billion euros respectively. Rhinitis occurs in over 100 million people in Europe, and indirect costs are enormous. Asthma is a common risk factor for COPD. CRDs impact ageing and should be prevented, recognised and managed across the life cycle to promote active and healthy ageing (AHA). There is an urgent need to act globally. European Innovation Partnerships (EIPs) aim to enhance EU competitiveness and tackle societal challenges through research and innovation. To tackle the potential of ageing in the EU, the European Commission, within its Innovation Union policy, launched the EIP on AHA (between the Directorate General for Health and Food Safety (DG Santé) and Directorate General for Communications Networks, Content and Technology (DG CONNECT)). The B3 Action Plan promotes integrated care models for chronic diseases, including the use of remote monitoring. The initiative AIRWAYS-ICPs (integrated care pathways for airway diseases) has been approved by the EIP on AHA as the model of chronic diseases of the B3 Action Plan. It is a Research Demonstration Project of the World Health Organization's Global Alliance against Chronic Respiratory Diseases (GARD). AIRWAYS-ICPs was initiated in 2013 by the WHO Collaborating Centre of Montpellier and the EIP on AHA Reference Site MACVIA-LR (Contre les MAladies Chroniques Pour un Vieillissement Actif en Languedoc-Roussillon, France) led by the Région Languedoc-Roussillon (France). ; Peer reviewed

© 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). ; Anti-obesity drugs in the amphetamine (AMPH) class act in the brain to reduce appetite and increase locomotion. They are also characterized by adverse cardiovascular effects with origin that, despite absence of any in vivo evidence, is attributed to a direct sympathomimetic action in the heart. Here, we show that the cardiac side effects of AMPH originate from the brain and can be circumvented by PEGylation (PEGyAMPH) to exclude its central action. PEGyAMPH does not enter the brain and facilitates SNS activity via theβ2-adrenoceptor, protecting mice against obesity by increasing lipolysis and thermogenesis, coupled to higher heat dissipation, which acts as an energy sink to increase energy expenditure without altering food intake or locomotor activity. Thus, we provide proof-of-principle for a novel class of exclusively peripheral anti-obesity sympathofacilitators that are devoid of any cardiovascular and brain-related side effects. ; This work was supported by the Fundação Para a Ciência e Tecnologia (FCT - PTDC-BIM-MET-3750-2014 and LISBOA-01-0145-FEDER-030892), the European Molecular Biology Organization (EMBO - Installation Grant 3037), the Human Frontier Science Program (HFSP - RGY0070/2016), Maratona da Saúde (Diabetes - 2016), the European Research Council (ERC-2017-COG-771431), and the Howard Hughes Medical Institute/Wellcome International research scholar award (HHMI - 208576/Z/17/Z). G.J.L.B. is a Royal Society university Research Fellow (URF\R\180019) and FCT Investigator (IF/00624/2015). B.J. and A.K. were supported by the BBSRC (BB/M027252/1/bbsrc). We also acknowledge the Portuguese Mass Spectrometry Network (LISBOA-01-0145-FEDER-022125), the Project EU_FT-ICR_MS, funded by the European Union Horizon 2020 research and innovation program under grant agreement no. 731077. The contribution of Y.S., M.O., and F.C. was supported by Ministerio de Ciencia, ...